Anti-inflammatory Supplements to Manage Crohn’s Disease

Crohn's disease is an inflammatory bowel disease that can affect any part of the digestive tract. In people with Crohn's, the immune system attacks the digestive tract, causing chronic inflammation that can lead to a range of symptoms, including abdominal pain, diarrhea, fatigue, and weight loss.  As was in the case of a recent client, we found it through iron-deficiency anemia caused by blood loss in his stool.

The inflammation in Crohn's disease is characterized by an overproduction of certain immune cells and pro-inflammatory cytokines, which are molecules that help to regulate the immune response. This chronic inflammation can damage the lining of the digestive tract and the formation of ulcers, scar tissue, and strictures (narrowing of the intestinal walls).

While the exact triggers of this immune response are not fully understood, there are several factors that may contribute to the development of Crohn's, including genetics, environmental factors, and an abnormal response to gut bacteria. One of the most commonly studied is a type of bacteria called adherent-invasive Escherichia coli (AIEC), which has been found in higher numbers in the intestines of people with Crohn's disease compared to healthy individuals. AIEC is known to invade and replicate within immune cells in the gut, leading to chronic inflammation and tissue damage. Other bacteria associated with Crohn's disease include species in the Bacteroides, Ruminococcus, and Enterococcus genera. However, more research is needed to fully understand the complex interactions between gut bacteria and the development and progression of Crohn's disease in order to develop better treatments and therapies.

In general, people with Crohn's disease may have difficulty absorbing certain nutrients due to inflammation and damage to the intestinal lining. The nutritional supplement regimen for someone with Crohn's disease will depend on the individual's specific needs and nutritional status. Here is information on a few anti-inflammatory supplements that may be helpful for people with Crohn's disease:

1. Curcumin: Curcumin is the active ingredient in turmeric, a spice commonly used in Indian cuisine. Curcumin has been shown to have potent anti-inflammatory properties and may help reduce inflammation in the digestive tract. Several studies have suggested that curcumin supplements may be helpful in reducing inflammation and symptoms in people with Crohn's disease. However, it is important to note that curcumin supplements may not be appropriate for everyone and may interact with certain medications. In addition, curcumin has low bioavailability, meaning it is not well absorbed by the body when consumed orally, making it important to use high-quality pharmaceutical-grade supplements like those in my Fullscripts account. Generally, 500-2,000 mg per day have been used in studies to reduce inflammation and symptoms in people with Crohn's disease.

2. Probiotics: Probiotics are beneficial bacteria that can help restore balance to the gut microbiome. Certain strains of probiotics may help reduce inflammation and improve symptoms in people with Crohn's disease.  Bifidobacterium infant, VSL #3 (a high-potency probiotic blend that contains eight different strains of bacteria), Lactobacillus rhamnosus GG, and Bifidobacterium animalis lactis DN-173 010 have all been shown to reduce inflammation in the gut and improve symptoms in people with Crohn's disease.  It is important to note that not all probiotics are created equal. It is important to choose a probiotic supplement that contains strains that have been shown to be beneficial for people with Crohn's disease. 

3. Omega-3 fatty acids: Omega-3 fatty acids are essential fatty acids that have anti-inflammatory properties. Several studies have suggested that omega-3 supplements, such as fish oil, may help reduce inflammation and symptoms in people with Crohn's disease. Omega-3 supplements may also help improve the balance of beneficial bacteria in the gut. Dosages of omega-3 supplements can vary depending on the concentration of EPA and DHA. Generally, 1-3 grams of combined EPA and DHA per day have been used in studies to reduce inflammation and symptoms in people with Crohn's disease.

4. Quercetin: Quercetin is a flavonoid in many fruits and vegetables, such as apples, onions, and broccoli. Quercetin has antioxidant and anti-inflammatory properties and may help reduce inflammation in the digestive tract. Several studies have suggested that quercetin supplements may be helpful for reducing inflammation and symptoms in people with Crohn's disease. Generally, 500-1,000 mg per day have been used in studies to reduce inflammation and symptoms in people with Crohn's disease.

5. Vitamin D: Vitamin D deficiency is common in people with Crohn's disease and may contribute to inflammation. Vitamin D supplements can help ensure adequate levels and may help reduce inflammation. Several studies have suggested that vitamin D supplements may be helpful for reducing inflammation and symptoms in people with Crohn's disease. Dosages of vitamin D supplements can vary depending on the individual's lab values. Generally, 1,000-5,000 IU per day have been used in studies to reduce inflammation and symptoms in people with Crohn's disease.

Anti-inflammatory supplements can be a helpful addition to the treatment plan for individuals with Crohn's disease. Curcumin, omega-3 fatty acids, and quercetin are some of the most studied supplements for their anti-inflammatory properties. Probiotics, including VSL#3, Lactobacillus rhamnosus GG, and Bifidobacterium animalis lactis DN-173 010, have also shown promise in reducing inflammation and improving symptoms of Crohn's disease. However, it is important to consult a healthcare professional before starting any new supplement regimen, as some supplements may interact with medications or have unwanted side effects. Additionally, supplements should never be used as a replacement for a nutrient-dense, well-balanced diet.

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